Negative regulation of T cell activation.
نویسنده
چکیده
T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based activation motifs and tyrosine kinases, inhibitory signals are delivered by tyrosine phosphatases. Unresponsiveness is also induced by modulation of signaling components of the T cell receptor complex.
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ورودعنوان ژورنال:
- Current opinion in immunology
دوره 10 3 شماره
صفحات -
تاریخ انتشار 1998